Vishal Upadhyay

Innovative life scientist with background in developing and implementing experimental studies across various biological systems. Skilled in data analysis, scientific writing, and collaboration with multidisciplinary teams to advance research objectives. Demonstrated ability to innovate in laboratory settings, leading to improvements in research methodologies and contributing to published findings. Committed to solving complex biological problems through rigorous experimentation and critical thinking.

• 25th INDO-US Flow Cytometry Workshop, 2024, Lucknow, UP, India
• Optimization Techniques for Immunohistochemistry (IHC) and Immunocytochemistry (ICC), 08/23/22, Lucknow, UP, India
• Humane care of Experimental Animals & Basic Animal handling and procedural Techniques, 12/20/19 to 12/27/19, Lucknow, UP, India
• Separation of Proteins and their detection by fluorescent Immunoblotting, 07/19/19, Lucknow, UP, India

• Qualified CSIR (Life Sciences) Research fellowship and eligibility for lectureship (NET) June 2018, CSIR-HRDG, Govt. of India with All India Rank 65.
• Qualified Graduate Aptitude Test in Engineering (GATE Life sciences, 2018) with All India Rank 446
• Second Position in Masters of Science in Zoology, University of Allahabad, Allahabad (2018)

• RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover., Vishal Upadhyay, AK Singh, S Sharma, A Sethi, S Srivastava, S Chowdhury, S Siddiqui, N Chattopadhyay, AK Trivedi, Journal of Cellular Physiology, 2024
• Hakai, a novel Runx2 interacting protein augments osteoblast differentiation by rescuing Runx2 from Smurf2-mediated proteasome degradation., Vishal Upadhyay, S Sharma, A Sethi, AK Singh, S Chowdhury, S Srivastava, S Mishra, S Singh, N Chattopadhyay, AK Trivedi, Journal of Cellular Physiology, 2024
• RNF138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in AML., AK Singh, Vishal Upadhyay, A Sethi, S Chowdhury, S Mishra, S Siddiqui, SP Verma, MLB Bhatt, AK Trivedi, Biochemical Journal, 2024
• Nemo-Like Kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML., AK Singh, G Thacker, Vishal Upadhyay, M Mishra, A Sharma, A Sethi, S Chowdhury, S Siddiqui, SP Verma, A Pandey, MLB Bhatt, AK Trivedi, The FEBS journal, 2024
• Anti-Microbial Drug Metronidazole Promotes Fracture Healing: Enhancement in the Bone Regenerative Efficacy of the Drug by a Biodegradable Sustained-Release In Situ Gel Formulation., S Duggal, S Sharma, N Rai, D Chauhan, Vishal Upadhyay, S Srivastava, K Porwal, C Kulkarni, AK Trivedi, JR Gayen, PR Mishra, N Chattopadhyay, S Pal, Biomedicines, 2024
• Ormeloxifene, a nonsteroidal antifertility drug promotes megakaryocyte differentiation in leukemia cell line K562., M Mishra, AK Singh, G Thacker, Vishal Upadhyay, S Sanyal, AK Trivedi, Cell Biology International, 2023
• AIP4 regulates adipocyte differentiation by targeting C/EBPα for ubiquitin-mediated proteasomal degradation., S Chowdhury, AK Singh, S Srivastava, Vishal Upadhyay, A Sethi, S Siddiqui, AK Trivedi, Journal of Cellular Biochemistry, 2023
• Dexamethasone induces cancer mitigation and irreversible senescence in lung cancer cells via damaging cortical actin and sustained hyperphosphorylation of pRb., S Srivastava, S Siddiqui, S Singh, S Chowdhury, Vishal Upadhyay, A Sethi, AK Trivedi, Steroids, 2023
• SOX4-mediated FBW7 transcriptional upregulation confers Tamoxifen resistance in ER+ breast cancers via GATA3 downregulation., A Sharma, G Thacker, M Mishra, AK Singh, Vishal Upadhyay, S Sanyal, AK Trivedi, Life Sciences, 2022
• Proteomic analysis of TGFβ-induced A549 secretome identifies putative regulators of epithelial-mesenchymal transition., A Sharma, Vishal Upadhyay, M Sarkar, M Mishra, G Thacker, AK Trivedi, Biotechnology and Applied Biochemistry, 2022
• FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1., M Mishra, G Thacker, A Sharma, AK Singh, Vishal Upadhyay, S Sanyal, SP Verma, AK Tripathi, MLB Bhatt, AK Trivedi, Mol Cancer Research, 2021