Manoj Vallabha
Downstream Process Development
House No: 1-71, Bannuwada (Vill), Tekkali, Srikakulam
Summary
Highly motivated individual committed to hard work and intensive analysis. Flexible and polished Senior Research Associate promoting well-developed skills Protein purification and Data analysis
Overview
7
7
years of professional experience
6
6
years of post-secondary education
3
3
Languages
Work History
Research Associate
Dr.Reddys laboratories Biologics
Bachupally, Hyderabad
04.2021 - Current
- Profound knowledge in Optimization and purification of protein molecules in R&D level by using various chromatography techniques.
- Resin screening, Dynamic binding establishment and Optimization of scalable process by various chromatography techniques.
- Ultrafiltration- Optimization and Scale up.
- Scale up proposal for various unit operations with facility fitment assessment.
- Scale down model proposal & Execution and Qualification
- Gathered, arranged and corrected research data to create representative graphs and charts highlighting results for presentations.
- Set up equipment, organized inventory and maintained facilities.
- Preparation, periodic reviews and revision of standard operating procedures.
- Filtration sizing studies such as Vmax, Pmax and Tmax
Senior Research Associate
Syngene International limited
Bangalore
02.2018 - 04.2021
- Purification of therapeutic proteins by using Affinity, Ion exchange and Gel-Filtration chromatography.
- Analyzing the quality of proteins by SDS-PAGE analysis
- Identifying the Expressed proteins by using Western blot analysis.
- Purity and titer estimation of recombinant proteins by SEC-HPLC and Protein-A HPLC respectively.
- Initiated, planned and executed research projects under supervision of senior scientist.
- Maintained detailed records of project data and materials, updating information when changes arose.
- Achieved project objectives by troubleshooting experiments and testing practical and creative solutions.
- Designed and executed studies to support usability of solutions, analyze data and provide actionable recommendations to project team.
Assistant Manager
Dr.Reddys Laboratories limited, Biologics Unit
Bachupally, Hyderabad
09.2016 - 02.2018
- Demonstrated ability to manage human and material resources towards the achievement of stated objectives, to plan and manage work and to lead, motivate and provide effective guidance to a team of professional and support staff.
- Well experience in handling of chromatography system, columns, TFF (UFDF skid) and centrifuge, proficient in Column packing and its finding the Integrity,
- Trouble shooting of downstream operations, mainly in chromatography and UFDF stage, as well as centrifugation, VF, and Depth filtration.
- Profound knowledge of gap assessment for continuous operational improvement. well known of using the single use systems in downstream process.
- Preparation of BMR and SOP and incorporate improvements in approved documents during the periodic review or as per CAPA as and when required.
Jr.Executive
Biological E Limited
Shameerpet, Hyderabad
06.2015 - 10.2016
- Involved in HIB polysaccharide vaccine Manufacturing: Polysaccharide Purification by Ultrafiltration and Conjugation with Proteins (TTD).
- Conjugated protein Purification by filtration and Chromatography techniques.
- Protein and Polysaccharide estimation by BCA and Orcinol assay respectively.
Education
Bachelor of Technology - Biotechnology
Jawaharlal Nehru Technological University
Kukatpally, Hyderabad 09.2008 - 05.2012
Master of Technology - Biotechnology
Jawaharlal Nehru Technological University
Kukatpally, Hyderabad 05.2013 - 05.2015
Skills
Chromatography (Column Chromatography)
Timeline
Research Associate
Dr.Reddys laboratories Biologics
04.2021 - Current
Senior Research Associate
Syngene International limited
02.2018 - 04.2021
Assistant Manager
Dr.Reddys Laboratories limited, Biologics Unit
09.2016 - 02.2018
Jr.Executive
Biological E Limited
06.2015 - 10.2016
Master of Technology - Biotechnology
Jawaharlal Nehru Technological University
05.2013 - 05.2015
Bachelor of Technology - Biotechnology
Jawaharlal Nehru Technological University
09.2008 - 05.2012
Similar Profiles
Sudhanshu Shekhar SiddharthaSudhanshu Shekhar Siddhartha
Territory Manager at Dr.Reddys LaboratoriesTerritory Manager at Dr.Reddys Laboratories
Vijay Pal Singh SikarwarVijay Pal Singh Sikarwar
Scientist - Process Development at Dr.Reddys Laboratories Ltd.Scientist - Process Development at Dr.Reddys Laboratories Ltd.
MUDASSIR SHAIKHMUDASSIR SHAIKH
AREA BUSINESS MANAGER at Dr.Reddys labAREA BUSINESS MANAGER at Dr.Reddys lab