Meghal J Shah
Mumbai
Summary
Research Associate specializing in biotransformation, enzyme kinetics, and downstream processing, driving patented projects and high-yield, scalable biotech solutions.
Overview
1
1
year of professional experience
1
1
Certification
Work History
Research Associate
Embio Limited
Mahad
08.2024 - Current
- Led a patented biotransformation projects, improving product conversion rates from 40 % to 85 %, enhancing process efficiency and scalability.
- Led a lab-scale biotransformation project, optimizing process conditions to increase product yield from 75% to 90%.
- Directed a patented biotransformation project, improving product conversion from 40% to 85%, enhancing process efficiency and scalability.
- Participated in technology transfer activities, demonstrating optimized biotransformation processes to the production team at 15 kL and 100 kL scales, ensuring successful scale-up and process handover.
- Managed and optimized shake flask biomass batches, overseeing PC-1 inoculation, induction, and harvest, resulting in a yield increase from 12 to 17 g/L.
- Applied insights from scientific literature to resolve project challenges and optimize experimental outcomes.
- Maintained glycerol stock cultures for genetically modified bacterial strains to ensure long-term strain stability, and reproducibility of experimental results.
- Revised and updated Standard Operating Procedures (SOPs) to align with current laboratory practices, regulatory standards, and process improvements.
- Led the optimization of the biotransformation of L-Norephedrine in a 1 L glass fermentor, achieving an 85% product yield through the parameter optimization of fermentation and reaction conditions.
- Conducted the recovery and purification of Levodopa using optimized downstream processing techniques, ensuring high product purity and yield.
- Analyzed HPLC chromatograms to glean data and interpret trends, and prepared reports and presentations for senior management and R&D reviews.
- Led enzymatic assay optimization and kinetic characterization of pyruvate decarboxylase and transaminase enzymes, developing protocols, and determining Km and Vmax to evaluate enzyme efficiency and substrate specificity.
Education
Master of Science - Biotechnology
Amity University Mumbai
Mumbai06.2023
Bachelor of Science - Biotechnology
Pillai College of Arts, Commerce And Science
Navi Mumbai05-2021
Skills
- Process optimization at lab scale
- Downstream operations
- Experimental methodologies
- Data analytics
- Upstream optimization strategies
- GMP documentation
Hobbies and Interests
Reading, Sketching and Travelling
Achievements
Detection of genetically modified food products in the Indian market using PCR-based GMO detection kit: A pilot study, Journal of Food Safety and Hygiene, 03/22/21
Certification
Clinical data management.
Timeline
Research Associate
Embio Limited
08.2024 - Current
Master of Science - Biotechnology
Amity University Mumbai
Bachelor of Science - Biotechnology
Pillai College of Arts, Commerce And Science