N. V. S. K. Rao
Research Scientist
Hyderabad,TG
Summary
Research Scientist with ~17 years of experience in small-molecule drug discovery, specializing in synthetic organic chemistry, medicinal chemistry, and SAR-driven lead optimization. Demonstrated success across Target-to-Hit, Hit-to-Lead, and Lead Optimization programs with strong expertise in heterocyclic chemistry, stereoselective synthesis, scale-up, patents, and publications.
Overview
17
17
years of professional experience
3
3
Languages
Work History
Research Scientist – Drug Discovery (Medicinal Chemistry)
Jubilant Biosys
10.2006 - 09.2021
- Designed and synthesized novel small-molecule libraries for multiple discovery programs.
- Led SAR exploration and lead optimization to improve potency and drug-like properties.
- Executed complex heterocyclic and chiral syntheses.
- Conducted route scouting, process optimization, and scale-up.
- Collaborated with biology and DMPK teams for compound progression.
- Maintained experimental documentation and supported patent drafting.
Research Chemist
Chembiotek Research International
10.2005 - 09.2006
- Synthesis and characterization of medicinal chemistry intermediates.
Process Chemist
AV Rama Rao Research Foundation
06.2004 - 09.2005
- Process development and scale-up of pharmaceutical intermediates.
Education
M.Sc. - Organic Chemistry
Andhra University
B.Sc. - Chemistry
Andhra University
MBA - Finance
Andhra University
Skills
Medicinal Chemistry & Drug Discovery Strategy
SAR Design, Interpretation & Optimization
Target → Hit → Lead Optimization
Design & Synthesis of Novel Molecular Entities (NCEs)
Heterocyclic, Peptide & Chiral Chemistry
Multi-step Organic Synthesis & Route Scouting
Reaction Scale-up (mg → kg)
Structure Elucidation (NMR, LC-MS, IR, HPLC)
Patent & Literature Intelligence (Reaxys, SciFinder, Beilstein)
Publications & Intellectual Property
International Patent: WO 2019/077631 A1 – Novel PAD4 inhibitor heterocyclic compounds.
Timeline
Research Scientist – Drug Discovery (Medicinal Chemistry)
Jubilant Biosys
10.2006 - 09.2021
Research Chemist
Chembiotek Research International
10.2005 - 09.2006
Process Chemist
AV Rama Rao Research Foundation
06.2004 - 09.2005
B.Sc. - Chemistry
Andhra University
MBA - Finance
Andhra University
M.Sc. - Organic Chemistry
Andhra University