Rajendra Ganpati Powar
Dhayari. Pune
Summary
A Chemistry professional with 17 years of experience in the technology transfer and process development, from route scouting to Process Development and cGMP manufacturing of drug substances .Also lot of experience in CRO, agrochemicals ,speciality chemicals, peptides synthesis and drug discovery process. Experience in technology transfer from milligram scale to plant with a QBD principles. I have managed all aspects of the Research and Development R&D project from planning and budgeting to scale-up and production support. Proven record in leading, managing, and delivering projects in a global environment. Skilled in project management, risk assessments, scientific & technical writing, and regulatory documentation. An accomplished in the development of a sustainable process for the manufacture of KSM and API, and the digital transformation of process research laboratories. Forward-thinking in process development with technical knowledge, leadership abilities and planning strengths to oversee research and development activities.Experience in employing concept of quality by design (QbD) and design of experiments (DOE) in product development.
Overview
17
17
years of professional experience
Work History
Research Scientist
USV Pvt. Ltd
Bengaluru
01.2023 - Current
- Worked on the route scouting, design, synthesis of various new modified amino acids and specialty chemicals.
- Also worked on synthesis of different resins for synthesis of solid phase peptide synthesis .
- Expertise in preparation of peptide and process development
- Also involved identification, characterization and synthesis of desired impurities.
Research Scientist
Lupin Ltd
Pune
10.2009 - 10.2022
- Expert in library synthesis of small molecules in milligram scale
- Expert in the creation of processes for novel medicinal compounds from the milligram to multikilogram scale.
- Troubleshooting of synthetic issues and making alternative synthetic strategies by proper literature search by various scientific databases such as scifinder and reaxys.
- Drive product development and scale up at 3rd party manufacturing sites.
- Expertise in synthetic chemistry, which includes retrosynthetic analysis, design and optimization of multi-step synthetic routes for novel small molecules, macrocycle synthesis, heterocyclic chemistry & enantioselective synthesis.
- Develop new product purification protocols to purify and characterize compound using variety of techniques.
- Well known the application and handling of manual and automated column chromatography purification techniques (Biotage, yamzen, grace, Teledyne isco combiflash purifiers).
- Addition to this developing effective communication and customer focus with cross functional team members regarding project work.
- Skilled at communicating scientific work in the form of presentations, poster, written report and updates.
- Familiar with documentation procedures, ISO audits, calibration and control records, estimating, raw material procurement, RFPs, project design and execution, customer update, research data management.
- Regular and accurate updating electronic lab note book and data on regular basis.
- Conducting laboratory experiments for process development and optimization.
- By estimating activities and resources, developing the project's actual schedule and budget according to scope, time, cost, procurement, and planning activities.
- Holding meetings with important stakeholders on a regular basis to keep everyone informed and to discuss any outstanding technical concerns
Research Scientist
INNOVASYNTH TECHNOLOGIES (I) LTD. KHOPOLI
Khopoli
05.2007 - 09.2009
- Develop a safe and environmentally friendly process by minimizing waste
- Vast experience in of synthesis of protected nucleoside, phosphoramidite and purification of phosphoramidite.Also work in carbohydrate chemistry
- Minimize raw material cost
- Search and explore new reagents, catalysts, and solvents to reduce the total cost of the production
- Minimize the number of steps and isolations
- Recycle and reuse some of the raw materials, catalysts and solvents Performing laboratory validations to create documentary evidence that provides a high level of assurance that the process is consistently reproduced according to the specifications and quality characteristics at the laboratory scale
- Ability to handle the project independently
- Involved in day-to-day process related troubleshooting.
Research Trainee
Excel Industries Ltd
Roha
06.2006 - 05.2007
- Experienced in Process Evaluation, Optimization, Process Development and troubleshooting for assigned products
- Experienced in handling moisture sensitive, light sensitive reactions
- Take safety precautions when handling any corrosive or pyrophoric reagents.
Education
Master of Science - Organic Chemistry
Savitribai Phule Pune University
Pune06.2006
Bachelor of Science - Chemistry
Shivaji University
Kolhapur01.2003
Skills
- Route scouting and Process development on QBD principles
- Experience in employing concept of quality by design (QbD) and design of experiments (DOE) in product development
- Impurity profiling ,identification and characterization
- Technology transfer from lab to plant scale
- Purification of chiral molecules with chiral resolution and different crystallization techniques
- Proven track record of synthesis of new API and KSM with cGMP on plant scale
- Peptide and resine synthesis ,
- Control ongoing operations and activities
- process safety and critical point identification
- root cause analysis in process development
- Conversant with various spectroscopic techniques, 2-D NMR, LCMS,IR for different classes of compounds
- Familiar with MS OFFICE tools, ACD, ISIS Draw and CHEMDRAW and mnova software for NMR interpretation
- Familiar with search on line databases such as, Sci-finder and Reaxys
- Familiar with traditional and automated purification methods
- Including preparative TLC, column and flash chromatography
- Additionally, handling knowledge of GC and HPLC Chromatography
- Effective teamwork, presentation, and communication skills
- Capable of handling collaborative and independent projects;
- Weekly updates on project status and presentations to upper Management
- Departmental coordination to ensure a project's smooth Implementation
- Time-management and decision-making abilities
- Control ongoing operations and activities
- Also familiar with project management techniques including SWOT analysis,project scheduling,timeline and the preparation of Gantt charts
- Digital transformation in process research lab to maintaining electronic lab note book , L2LMS learning module,inventory system
Interests
compounds, Resolving Product Query
Strengths:
, Confidence, coachable, team player, out of the box thinking, innovation driven, target oriented,
hard worker, patience, good communication.
Interests:
Experimenting in lab, Internet browsing, reading books, travelling.
Additional Information
- Project management,project scheduling,project management techniques and tools.
Affiliations
- Discovery of isoquinoline and naphthyridinone based inhibitors of poly(ADPribose)polymerase-1 (PARP1) as anticancer agents:Strucure activity relationship and preclinical characterization.
Bioorganic and medicinal chemistry, 2020, 28 (24), 115819.
- On-water reaction of (thio)isocyanate: A sustainable Process for the Synthesis of Unsymmetrical (thio) urea’s
Org. Process Res. Dev. XXXX,XXX,XXX-XXX
Patents:
- Methods, processes and intermediates for preparing chroman compounds .
AU2021207775 (A1);CA3166512 (A1);CN114981253 (A);
WO2021144814 (A1);BR112022013865 (A2)
- Process for preparing chroman compounds AU2020386871 (A1); CA3158696 (A1); CN114929680 (A); CO2022008539 (A2; ECSP22048528 (A); EP4061805 (A1); IL292734
Timeline
Research Scientist
USV Pvt. Ltd
01.2023 - Current
Research Scientist
Lupin Ltd
10.2009 - 10.2022
Research Scientist
INNOVASYNTH TECHNOLOGIES (I) LTD. KHOPOLI
05.2007 - 09.2009
Research Trainee
Excel Industries Ltd
06.2006 - 05.2007
Master of Science - Organic Chemistry
Savitribai Phule Pune University
Bachelor of Science - Chemistry
Shivaji University
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