Summary
Overview
Work History
Education
Timeline
Skills
Publications
Seclect Workshops & Training
BusinessAnalyst
Ratnika Sharma

Ratnika Sharma

PhD, Research Scientist
New Delhi

Summary

Ph.D. In Biotechnology with post-doctoral research experience in regenerative medicine, hypoxia biology, and natural product-based therapeutics. Skilled in developing In vitro and In vivo models for ocular diseases, with expertise in molecular, cellular, and bioinformatics techniques. Strong publication record and proven ability to translate research into therapeutic applications.

Overview

14
14
years of professional experience

Work History

Associate Research Scientist

Shroff Pandorum - Center for Ocular Regeneration, Dr. Shroff’s Charity Eye Hospital
05.2024 - Current
  • Working on cell- and tissue-based regenerative medicine platforms aimed at ocular repair, concentrating on developing and validating in-vitro and pre-clinical models of eye injuries to examine cellular responses, neuroprotection, and tissue regeneration for translational therapeutic applications
  • Leading research effort on understanding molecular characterisation of Pterygium

Post-Doctoral Research

Institute of Liver and Biliary Sciences
11.2023 - 05.2024
  • Studied liver disease mechanisms and the protective role of Ayurvedic drugs using rodent models; performed animal handling and biochemical analysis of plasma and tissue samples.

Post-Doctoral Research

Defense Institute of Physiology & Allied Science (DRDO)
10.2022 - 11.2023
  • Researched disease mechanisms and worked on developing cardiovascular therapies using natural products and bioactive compounds for stress induced by hypobaric hypoxia on rodent models (rat/mice) and C2C12 myoblast cells

Ph.D. Candidate

Guru Gobind Singh Indraprastha University
09.2015 - 02.2023
  • Drug discovery on nutraceuticals for anticancer activity against liver cancer (HepG2) cells; identified bioactive compounds via liquid chromatography and applied in vitro assays with in silico methods (molecular docking, molecular dynamics).

Project Fellow

Guru Gobind Singh Indraprastha University
05.2013 - 05.2018
  • Worked as junior and senior research fellow in University Grants Commission funded project in identification and evaluation of bioactive constituents from plants (cereals/millets).

Research Intern

Defense Institute of Physiology & Allied Science (DRDO)
02.2012 - 06.2012
  • Studied physiological effects of hypoxia-induced stress in male Sprague Dawley rats. Evaluated role of Cordyceps sinensis in mitigating oxidative stress from experimental hypobaric hypoxia.

Education

Ph.D. - Biotechnology

Guru Gobind Singh Indraprastha University
02.2023

Master of Science - Biotechnology

Chaudhary Charan Singh University
05-2012

Post-Graduate Diploma - Bioinformatics

Jamia Hamdard University
06-2010

Bachelor of Science - Life Sciences

Gargi College, University of Delhi
06-2009

Timeline

Associate Research Scientist

Shroff Pandorum - Center for Ocular Regeneration, Dr. Shroff’s Charity Eye Hospital
05.2024 - Current

Post-Doctoral Research

Institute of Liver and Biliary Sciences
11.2023 - 05.2024

Post-Doctoral Research

Defense Institute of Physiology & Allied Science (DRDO)
10.2022 - 11.2023

Ph.D. Candidate

Guru Gobind Singh Indraprastha University
09.2015 - 02.2023

Project Fellow

Guru Gobind Singh Indraprastha University
05.2013 - 05.2018

Research Intern

Defense Institute of Physiology & Allied Science (DRDO)
02.2012 - 06.2012

Ph.D. - Biotechnology

Guru Gobind Singh Indraprastha University

Master of Science - Biotechnology

Chaudhary Charan Singh University

Post-Graduate Diploma - Bioinformatics

Jamia Hamdard University

Bachelor of Science - Life Sciences

Gargi College, University of Delhi

Skills

Animal cell culture

Publications

Research Papers 

  • Ratnika Sharma, Rawat, P., Singh, P., Kanojiya, S., & Gupta, P. (2022). Statistical optimization of
    ultrasound assisted extraction of free and bound phenolic acids, antioxidant and antibacterial activities
    and UPLC–MS/MS characterization from two varieties of Eleusine coracana. Journal of Food
    Measurement and Characterization, 16, 2086-2103.
  • Ratnika Sharma & Gupta, P. (2021). Nutraceutical potential of Pennisetum typhoides microgreens:
    In vitro evaluation of antioxidant and antibacterial activity and in silico Staphylococcus aureus FtsZ
    inhibition. Food Bioscience, 42, 101151.
  • Hailu, T., Ratnika Sharma., Mann, S., Gupta, P., Gupta, R. K., & Rani, A. (2021). Determination
    of bioactive phytochemicals, antioxidant and anti-inflammatory activity of Colchicum autumnale L.
    (Suranjanshireen). Indian Journal of Natural Products and Resources (IJNPR) [Formerly
    Natural Product Radiance (NPR)], 12(1), 52-60.
  • Optimized ultrasound assisted extraction of polyphenols from Pennisetum typhoides microgreens and
    evaluation of their antioxidant, antibacterial and antiproliferative activities against hepatocellular
    carcinoma. (Manuscript Under Preparation).
  • Metabolic Signatures of Hypobaric Hypoxia: A Plasma Profiling Study in Rats. (Manuscript Under
    Preparation).

Book Chapters 

  • Ratnika Sharma, Tulsawani R. Chapter 22. Nutraceuticals in alleviating aging. In: Tulsawani R,
    Vohora D, editors. Adaptation under stressful environments through biological adjustments and
    interventions; 2024. doi: 10.1007/978-981-99-7652-2_22
  • Majumdar S, Ratnika Sharma, Maithani R, Tulsawani R. Chapter 3. Activation of hypoxia-
    inducible factor under high altitude stress. In: Tulsawani R, Vohora D, editors. Adaptation under
    stressful environments through biological adjustments and interventions; 2024. doi:
    10.1007/978-981-99-7652-2_3
  • Jain R, Ratnika Sharma, Maithani R, Tulsawani R. Chapter 5. Expression of vascular endothelial
    growth factor at high altitude. In: Tulsawani R, Vohora D, editors. Adaptation under stressful
    environments through biological adjustments and interventions; 2024. doi:
    10.1007/978-981-99-7652-2_5
  • Maithani R, Yadav R, Ratnika Sharma, Tulsawani R, Chapter 21. Prevention of pro-inflammatory
    markers by medicinal mushrooms under stressful environment. In: Tulsawani R, Vohora D, editors.
    Adaptation under stressful environments through biological adjustments and interventions; 2024. doi:
    10.1007/978-981-99-7652-2_21.

Seclect Workshops & Training

  • Rodent Surgery – ILBS, New Delhi (2023)
  • Gene Cloning & Cell Culture in Anti-Cancer Drug Discovery – CSIR-IIIM, Jammu (2022)
  • Computational Biology & Network Pharmacology – Punjabi University, Patiala (2021)
  • Bioinformatics & Computational Tools – DTU, Delhi (2020); NIT, Jalandhar (2020)
  • Science Leadership – Central University of Punjab (2020)
  • In silico Drug Discovery & Design – AIIMS, Delhi (2015)
Ratnika SharmaPhD, Research Scientist