Ripanshu Thakur

Innovative chemist with background in pharmaceutical and chemical research. Skilled in conducting complex experiments, analyzing data, and synthesizing new compounds. Strong communicator, adept at presenting findings to stakeholders and collaborating with interdisciplinary teams for project advancement.

Experts in working with Scifinder, Reaxys, Organic Chemistry Portal, Sci Hub, Google Scholar, Chemdraw, pH meter, Rota vapor, Autoclave (for chemical reactions), Autoclave (for sterilization), High vacuum Distillation pump, Centrifuge, Sonicator, Incubator, Inoculation chamber, Muffle furnace, Microwave (for Organic reactions), Oven (material drying), UV chamber, CombiFlash column, Isolera, Lyophilizer, Flame gun, Oil bath, magnetic and mechanical stirrer, Grignard synthesis, Chlorination, Basic/acidic Hydrolysis, Knoevenagel condensation, Stobbe condensation, Michael addition, Resolution, Halogenation, Freidel craft alkylation/acylation, Esterification, Witting rearrangement, Deprotection, Hydroxylation, Suzuki coupling, Krapcho Decarboxylation, Pinner arrangement, Wolf kishner Reduction, Lactamization, Salt formation/breakage, Pressure reactions/ autoclave (up to 20kg/cm2), Raney nickel reactions, Sodium metal reactions, Sodium cyanide reactions, SMO/SPO formation, High temperature reactions (up to 220˚C), Low temperature reactions (15C), Moisture sensitive reactions, Crystallizations, High vacuum distillations, Column chromatography, Flash chromatography (Isolera), Oven drying, Tray drying (TD), Vacuum tray drying (VTD), Rota vapor drying, Rotatory cone vacuum drying (RCVD), Toluene using sodium metal, Tetrahydrofuran (THF) using Butylated hydroxyl toluene (BHT), aluminum turnings or Molecular sieves, Dimethyl sulfoxide (DMSO) using sodium chloride (NaCl), Dimethyl Formamide with distillation and molecular sieves, Methanol/Ethanol by distillation, calcium oxide, magnesium metal, Xylene using CaCl2, distillation & molecular sieve, Hexane/Heptane by Calcium hydride & Sodium metal, Sodium cyanide using Ferrous sulphate and Sodium Hypochlorite, Raney Nickel using Hydrochloric acid, Chlorine gas with sodium hydroxide solution, Sulphur dioxide gas with sodium hydroxide solution, Hydrogen pressure release using steam line/water dip, Thionyl chloride using sodium hydroxide/ sodium carbonate, Sodium Borohydride with Hydrochloric acid/water, Sodium metal with organic protic solvents, pH meter, Oven, Rota vapor, Autoclave, Vacuum pump, magnetic and mechanical stirrer

• High Performance Liquid Chromatography (HPLC)
• Gas Chromatography (GC)
• Thin Layer Chromatography (TLC)
• Ultraviolet spectroscopy (UV)
• Infrared spectroscopy (IR)
• Nuclear Magnetic Resonance spectroscopy (NMR)
• Mass Spectroscopy (MS)
• Liquid Chromatography Mass Spectroscopy (LCMS)

• Develop drug molecule and methods on grams (gm) to scale up (kg) and commercialization
• Ensures quality of drug molecule
• Comply with all applicable SOPs, GLP, GMP, housekeeping and safety regulations
• Review literature and patents (using scifinder)
• Complete chemical, physical or instrumental analysis accurately on any pharmaceutical product, in-process material, raw material or stability with some oversight
• Accurately record all variables, such as chemical type, amount, compound components, chemical temperature and test duration
• Process validations (grams and kilograms)
• Document critical observations pertaining to analytical testing in support of product development
• Participate in continuous improvement of methodology and technology and finding ways to save cost and increase efficiency
• Develop vendor qualification data for product commercialization
• Purifying product by column chromatography, crystallization and high vacuum distillation
• Working experience in production floor during product technology transfer till validation
• Adhere to safety standards during laboratory testing
• Perform other related duties as assigned to meet departmental and company objectives

• Independently synthesize and characterize novel organic compounds (milligram to gram scale)
• Selection of the most feasible route of chemical synthesis, right substrate, conditions to carry out the reaction in order to get the required product
• Structural elucidation using the entire range of Spectroscopic techniques like NMR, Mass, IR, UV, HPLC, etc
• Able to handle projects that involve synthesis of complex molecules which are not reported in literature
• Sound knowledge of Sterochemistry
• Literature search and route scouting (Sci Finder/ Reaxys)
• Designing Route of Synthesis of Novel compounds along several Experimental skills
• Isolation and Purification Techniques
• Able to consistently deliver projects within the targeted timelines
• To maintain laboratory records as per company policy
• Comply with all Good Laboratory Practices

• Rosuvastatin-C
• Lenovogestral-O
• Thiotepa-A
• Thiotepa-B
• Thiotepa-c

• Punjabi
• Hindi
• English

• Course in Clinical Diagnostic Technique, 71.0, Punjabi University, 2012-2013
• Diploma in Clinical Diagnostics Techniques, 50.0, Punjabi University, 2013-2014
• Executive Diploma in Pharmaceutical Regulatory Affairs, 8.06, Institute of Good Manufacturing Practices India, 2019-2020

• Total Experience: 7 Year 6 Months
• Age: 31
• Date of Birth: 11/05/94
• Gender: Female
• Religion: Hindu