N YOGARAJAN

Responsible for project functions including managing team.
Evaluating and writing the Request for Proposal for the oligonucleotide molecules.
Preparing business case studies and market strategy for Oligonucleotide
Developing and transfer the technology to scale up and executing in the pilot scale for Oligonucleotide.
Responsible for preparing weekly updates, preparation of development report and Gantt chart preparations.
Evaluate tech-pack protocol and perform reactions on gm to Kg scale.
Preparation cost sheet and requesting to other cross-functional team to evaluate requirement such as reactors, QC requirements including stability as well as validation.
Co-ordination with CFT team includes Analytical, Process engineering, Process Safety and Quality Assurance to deliver project with timeline.
Preparing TTD report and sharing across through production and QA for BMR preparation.
Well knowledge in Solid phase Synthesis of Oligonucleotide with different type of modification (Like Conjugation, backbone and modified RNA & DNA.Syngene International limited is an ISO 9001:2008, ISO 14001:2004, and OHSAS 18001:2007 certified company having GMP facilities. Syngene is an internationally reputed custom research and manufacturing organization.

• Responsible for project functions including managing team.
• Responsible for preparing weekly updates, preparation of development report and Gantt chart preparations.
• Evaluate tech-pack protocol and perform reactions on gm to Kg scale.
• Preparation cost sheet (RFP) and requesting to other cross-functional team to evaluate requirement such as reactors, QC requirements including stability as well validation.
• Involved and committed towards versatile projects and successfully completed.
• Complete co-ordination with Analytical, Process engineering, Process Safety and Quality Assurance to deliver project with timeline.
• Preparing TTD report and sharing across through production and QA for BMR preparation.
• Well knowledge in Solid phase Synthesis of Oligonucleotide with different type of modification (Like Conjugation, backbone and modified RNA & DNA.
• Experience with handling 2’-Fluoro, 2’-MOE, 2’-CET, 2’-OMe modification. Also phosphodiester and phosphorothioate backbone.
• Handled 5’ and 3’end modification with BHQ, FAM, HEX, phosphate, vitamin, cholesterol
• Developing the Cleavage & Deprotection process for different kind of oligonucleotide and also downstream process.
• Routine verification of analytical data like HPLC, GC, NMR, IR, XRD, DSC, TGA and Mass

Worked as a Scientist in Sequent Scientific Limited,

Bangalore, India.

• Expertise in route scouting and optimizations studies by varying possible process parameters to achieve maximum selectivity and yield Viz catalyst screening/ reagent loading / equivalent screening, temperature screening/mode of additions/duration of addition, solvent screening and alternate route scouting etc.,
• Development cost effective process for existing process.
• Route scouting and process development for in-house synthesis of key raw materials.

Worked as a R & D Research Executive in Orchid Chemicals & Pharmaceuticals Limited, Chennai, India.

• Ability to handle reactions from G scale to Kg scale and pilot scale.
• Following safety procedures & Standard operating procedures before starting any activities.
• Maintain the Lab note book online & good documentation practices.