Chiranjeevi B.

To emerge as a professional challenging leadership position, applying creative problem solving and fine management skills. Striving for organizational goals and objectives by continuously aiming towards innovation, perfection and excellence.

Talented Manager with expert team leadership, planning, and organizational skills built during successful career. Smoothly equip employees to independently handle daily functions and meet customer needs. Diligent trainer and mentor with exceptional management abilities and results-driven approach.

• Saptagir Laboratories Pvt Ltd, Manager, 03/01/21, Present, New synthetic routes designing for various drug molecules and R&D setting up, Daily reactions planning and implement new ideas to get best outputs, Daily and weekly report preparations to update project status for weekly update, Proficient in managing Process R&D activities, implement quality measures conduct process planning, suggest process enhancement solutions to reduce overall cost, Organize, planning, and coordination of the Process development, Literature search Scifinder, reaxys, New products evaluation, Design a non infringement route, Cost sheet as per journal yields and select low cost and best route, Process R&D setting up mg to gram level scale, Thorough knowledge of the acquisition and interpretation for analysis utilizing modern analytical techniques such as NMR, LCMS, GCMS, IR, SOR and HPLC., Yield co-efficient studies by using different reagents and solvents, Compare R&D and journal yield costs, Perform process safety studies and negative experiment studies, Specifications and KSMs vendor fixation, Intermediates and final in process specs fixation, Impurities identification and synthesis, Perform R&D process validations, Process development report preparation, Prepare in process specs reports, Perform trial batches at production level, Perform validation batches at production level, Organizing, planning and coordination of the entire batch production operations, Supervise all operations at production to adhere process for production chemists, Trouble shoot at production if any deviation happen, Perform OOS investigations, Team handling and continuous guidance on performing reactions, Completion of projects on time, Implementation of GMP practices and its adherence, Optimization and utilization of manpower and utility systems to achieve quality and quantity of the product, Training and upgradation of R&D personnel, Work experience under FDA environment, Maintain lab chemical inventories and order required chemicals., Edoxaban tosylate monohydrate and its intermediates, Acotiamide intermediates, Semaglutide intermediates, Triclabendazole, Terbinafine hydrochloride and its intermediate, Prasugrel hydrochloride and its intermediates, Ezetimibe, Solifinacine succinate, Tucatinib intermediate, Tafamidis meglumine
• Natco Pharma, Officer, 06/01/18, 03/31/21, Executing multi step synthetic strategies in a plant level scale ups and R&D towards the drug molecule synthesis., API process development, Impurity profiling and impurity synthesis., Specifications fixation for each and every intermediate as per Regulatory norms., Process development reports and DMF related documentation and DMF queries answering., Thorough knowledge of the acquisition and interpretation for analysis utilizing modern analytical techniques such as NMR, LCMS, GCMS, IR, SOR and HPLC., Literature search for the given scheme of synthesis of new chemical entities or scaffolds, Applying new synthetic methodologies on various target molecules., R&D setting up in a low cost manner by using conventional reagents., Expertise in various recrystallization techniques to improve yield and purity of each and every step molecule., Expertise in carrying out multi step synthesis of biologically active intermediates milligram to kilogram scales., Synthesis of solid phase peptides up to 32 amino acids chain., Solidphase peptide instrument CS-BIO instrument handled, Planning and execution of plant level batches within the stipulated time and expected purity levels., Recording the experimental observations in laboratory notebook and e-LNB., Well experience in literature search using Reaxys, Scifinder etc., Liraglutide, Semaglutide, Pimavanserin
• GVK BIO Sciences Pvt Ltd, Trainee Chemist to Research Associate, 11/01/11, 06/30/18, Involved in multi-step synthesis of various target molecules as requested by various Clients, including complex heterocyclic, peptide chemistry, carbohydrate and amino acid Derivatives., Having valuable research experience in Discovery research and contract research organizations., Highly familiar with Conventional (TLC, COLUMN...Etc), and Modern (HPLC, Prep HPLC, UPLC...Etc) chromatographic techniques., Preparation of dry solvents (Ether, THF, Methanol, etc....), Expertise in carrying out multi step synthesis of biologically active intermediates milligram to gram scales., Synthesis of peptides (mono, di and tri), amino acid synthesis., Carried out many reductions involving Pd catalysts (Pd/C, Pd (OH2) etc.), Platinum oxide, NaBH4, LiAlH4...etc., Planning and execution of synthetic and medicinal chemistry projects within the stipulated time with expected purity levels., Familiar with modern methods of organic synthesis such as using Radley’s parallel synthesizer., Inter conversion of functional groups in multistep synthesis, Expertise in handling reactions involving inert atmosphere and moisture sensitive reagents such as n-BuLi, sec-butyl lithium, DIBAL., Designing various synthetic routes for the lead molecules., Well versed in handling different metal mediated reactions like Suzuki, Heck, Sonogashira and Negishi., Well experience in literature search using Reaxys, Scifinder, Weekly update presentations preparation, Recording the experimental observations in laboratory notebook, e-LNB and citrix software., Worked for GSK, Novartis, Merck, Pfizer and BI client projects.