Chiranjit Polley

I am a qualified bioinformatician with 5 years of post-PhD experience in the field of bioinformatics and computational biology. I have a background in microbiology and my expertise lies in solving infectious disease-related problems using in-silico approaches. Presently, I am working on pathogen-host interactions at the molecular level, using network modelling approaches. In my future research endeavours, I would like to enhance my expertise on network modelling and implement these approaches to model infectious diseases. In addition to my expertise in research, I am also passionate about teaching.

• February 2021-March 2023, Post-doctoral Fellow, Network Biology lab, TAGC, INSERM, U01090, Marseille, France, Dr. Christine Brun, Research Director, CNRS, France, Study on SARS-CoV-2-host interactions in the light of Network Biology, Mining high throughput protein-protein interaction datasets, Application of various algorithms such as Random walk with restart (RWR) to cluster and model protein-protein and RNA-protein interaction networks, Integration of proteomic and transcriptomic data into protein-protein and RNA-protein interaction networks, Designing & Handling Computational workflows, Writing and Editing manuscripts based on Scientific results
• December 2018 - January 2021, UGC Dr. D.S. Kothari Post-doc Fellow, Dept. of Biophysics, Molecular Biology & Bioinformatics, University of Calcutta, Kolkata, India, Prof. Sudip Kundu, Mining Klebsiella pneumoniae-human host interaction network to prioritize candidate drug targets, Mining high throughput protein-protein interaction datasets, Development of computational workflows and scripts for data analysis, Integration of transcriptomic data into regulatory and protein-protein interaction networks & functional inference from the constructed network, Development of host target prioritization strategies, Writing and editing manuscripts based on scientific results
• May 2018-December 2018, FNRS Post-doctoral Fellow, GIGA-University of Liege, Liege, Belgium, Dr. Jean-Claude Twizere, Reprograming RNA splicing landscape of viral infections and cancers, Prediction of HTLV-1-host interactome based on Short linear motif (SLiMs) enrichment and structural disorder
• December 2011 - December 2017, Research scholar, Bose Institute, Kolkata, India, During PhD, the main aim of my study has been to explore the various underlying evolutionary forces that lead to the fixation and maintenance of gene overlapping in prokaryotic and viral genomes. My study reveals that overlapping genes are an integral part of thermophilic adaptation in prokaryotes. In addition, overlapping genes act as a significant genomic correlate of prokaryotic growth rate, with fast growing prokaryotes harboring an elevated frequency of gene overlapping. One of my recent publication is focused to explore the role of gene overlapping in retroviral pathogenesis mediating extensive host-virus interaction. In a nutshell, my study has elucidated some of the key implications of harboring overlapping genes in viral and prokaryotic genomes.

• Bengali
• English
• Hindi

• Blood Group: B
• Date of Birth: 06/25/86
• Gender: Female
• Marital Status: Married

• Dr. D.S. Kothari Post-Doctoral Fellowship awarded by UGC
• Senior Research Fellowship by Bose Institute, Govt. of India
• Junior & Senior Research Fellowship by Dept. of Biotechnology, Govt. of India
• Travel grants sanctioned by Dept. of Biotechnology for attending national conferences
• Qualified National Eligibility Test (NET) for lectureship in the year of 2010
• Qualified Graduate Aptitude Test (GATE) in the year of 2010
• University Grants Commission funded post-Doctoral grant

• Preprint, Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule, BioRxiv, 2021.08.25, https://www.biorxiv.org/content/10.1101/2021.08.25.457680v2
• Published Article, The Intricacy of the Viral-Human Protein Interaction Networks: Resources, Data, and Analyses, Frontiers in Microbiology, 2022, https://www.frontiersin.org/articles/10.3389/fmicb.2022.849781/full
• Published Article, Interplay between gene expression and gene architecture as a consequence of gene and genome duplications: evidence from metabolic genes of Arabidopsis thaliana, Physiology and Molecular Biology of Plants, 2022, https://link.springer.com/article/10.1007/s12298-022-01188-2
• Published Article, Exostosin-1 Glycosyltransferase Regulates Endoplasmic Reticulum Architecture and Dynamics, To be added, 2020, https://doi.org/10.1101/2020.09.02.275925
• Published Article, A molecular interaction map between Klebsiella pneumoniae and its human host reveals mechanisms of host cell subversion, Frontiers in Microbiology, 2020, https://www.frontiersin.org/articles/10.3389/fmicb.2021.613067/
• Published Article, Deciphering the intrinsic properties of fungal proteases in optimizing phytopathogenic interaction, Gene, 2019, https://doi.org/10.1016/j.gene.2019.06.024
• Published Article, Alanine substitution mutations in the DNA-binding region of a global staphylococcal virulence regulator affect its structure, function and stability, International Journal of Biological Macromolecules, 2018, https://doi.org/10.1016/j.ijbiomac.2018.03.045
• Published Article, The role of introns in the conservation of the metabolic genes of Arabidopsis thaliana, Genomics, 2018, https://doi.org/10.1016/j.ygeno.2017.12.003
• Published Article, Overlapping regions in HIV-1 genome act as potential sites for host-virus interaction, Frontiers in Microbiology, 2016, https://doi.org/10.3389/fmicb.2016.01735
• Published Article, Overlapping genes: A significant genomic correlate of prokaryotic growth rates, Gene, 2016, https://doi.org/10.1016/j.gene.2016.02.002
• Published Article, Overlapping genes: a new strategy of thermophilic stress tolerance in prokaryotes, Extremophiles, 2015, https://doi.org/10.1007/s00792-014-0720-3

• Prof. Tapash Ghosh, +917044770427, tapash@jcbose.ac.in
• Prof. Sudip Kundu, +918617272767, skbmbg@caluniv.ac.in
• Christine Brun, +33671623735, christine-g.brun@inserm.fr

• Singing
• Listening to Music
• Watching Movie
• Photography

• Conference on Informatics and integrated Biology (CIIB), December 17-19, 2014, Poster Presentation
• Hands-on Session of Computational Proteomics Workshop organized by Bioinformatics Centre, Bose Institute Kolkata, February 26, 2014, True
• Indian Institute of Madras (IITM)-Tokyo Tech joint Conference on 'Algorithm and Application of Bioinformatics', November 5-6, 2015, Poster Presentation
• Proteomics 2011 organized by Omics Group Conferences, June 6-8, 2011, Poster Presentation
• JOBIM 2022 Organised by Society for French Bioinformatics (SFBI), July 5-8, 2022, Poster Presentation
• Network Biology 2023 Organised by Cold Spring Harbour Laboratory (CSHL), NY, USA, March 14-18, 2023, Poster Presentation, Do SARS-CoV2 Genomic RNA act as sponge for Cellular RNA binding proteins