Jayita Goswami
Bangalore
Summary
Enthusiastic researcher with a keen interest in exploring complex scientific questions. Detail-oriented and committed to continuous learning, with a strong work ethic and a passion for discovery.
Overview
9
9
years of professional experience
Work History
Graduate Student
Indian Institute of Science
Bangalore
08.2017 - 03.2025
- Under the supervision of Prof. Kumar Somasundaram, Department of Microbiology and Cell Biology.
- PhD Research Topic: Exploring and Targeting Dysregulated GPCRs in Glioblastoma (GBM).
- Project 1: Integrative analysis of genetic and epigenetic regulation of GPCRs: Role in gliomagenesis, and identification of potential targets.
This research focuses on identifying genetically and epigenetically altered GPCRs, their associated ligands, and G-proteins in GBM using patient-derived datasets. It explores potential mechanisms of gene deregulation, including copy number variation, methylation, and miRNA regulation. Additionally, the study aims to validate the role of the upregulated gene GPR84 in GBM through in vitro and animal models by assessing the impact of its knockdown.
- Project 2: Mechanistic Insights into the Growth-Suppressive Role of the CT/CALCR Axis in GBM.
This study investigates the growth-inhibitory mechanism of the calcitonin (CT)/calcitonin receptor (CALCR) axis in glioblastoma (GBM) using a proteomic approach, Reverse Phase Protein Array (RPPA). Our findings reveal that CT effectively suppresses glioma progression by inhibiting key oncogenic effectors, YAP and TAZ, both in vitro and in vivo. Furthermore, molecular dynamics simulations of patient-derived CALCR mutations offer critical insights into structural and functional alterations that may contribute to receptor loss of function, potentially impairing its tumor-suppressive role.
MSc Project
Bidhan Chandra Krishi Viswavidyalaya
Mohanpur
07.2016 - 06.2017
- Under the supervision of Prof. Somnath Bhattacharyya, Department of Genetics and Plant Breeding, Bidhan Chandra Krishi Viswavidyalaya.
- Research Topic: To study the variation of yield and NAL1 gene in a set of contrasting rice genotypes.
Education
PhD - cancer Biology
Indian Institute of Science
Bangalore, India03.2025
Masters - Genetics and Plant Breeding
Bidhan Chandra Krishi Viswavidyalaya
Mohanpur, West Bengal, India07.2017
Skills
- Isolation of nucleic acids
- Cloning
- Mutational analysis
- qRT-PCR
- Primer/oligo designing
- SDS-PAGE
- Co-immunoprecipitation
- Pull-down assay
- Confocal, fluorescence, and bright-field microscopy
- Mammalian cell line culture
- Stem cell culture
- Human tumor tissue sample handling
- Flow cytometry analysis
- In vivo mouse experiments
- Subcutaneous injections, tail vein injections, intracranial injections
- Mouse perfusion
- Tissue harvesting
- Tissue processing
- Targeted drug delivery
- Scientific writing and editing
- Image preparation
- Figure Formatting
- Model design
- Sample preparation for RNA-Seq, mass spectrometry, and RPPA
- Data analysis using Microsoft Excel, GraphPad Prism, and SPSS
Personal Information
Nationality: Indian
Publications
- Goswami, J., Uttarasili, P., Prasasvi, K. R., Chowdhury, A., Garg, L., Srivastava, A., Somasundaram, K., Repurposing Calcitonin for Glioblastoma Treatment: Targeting YAP/TAZ via Hippo Pathway Activation (Under review in Neuro-Oncology).
- Goswami, J., Chowdhury, A., Prasasvi, K. R., Somasundaram, K., Panoramic View of GPCRs and Associated Genes in Glioblastoma (Manuscript in preparation).
- Sen, P., Purkayastha, S., Das, D., Goswami, J., Sen, S., Rai, P., Biswas, T., Bhattacharyya, P. K., Bhattacharyya, S., Yield-enhancing SPIKE allele from the aus-subtype indica rice and its allele-specific codominant marker, Journal of Genetics, https://doi.org/10.1007/s12041-021-01293-3, 2021.
Interests
Cancer Stem Cells & Therapy Resistance, Targeted Therapy & Precision Medicine, Tumor Microenvironment & Immunotherapy.
Training
- EMBO sponsored Chromatin, RNA, and Genome, 2023, Presented a poster on CALCR (Calcitonin Receptor) regulates the Hippo pathway by activating LATS1.
- International Conference on Biological Transactions from Molecules to Organism, 2023, Presented a poster on CT/CALCR axis activates the Hippo pathway.
- Gordon Research Conference on Stem Cells and Cancer, 2023, Presented a poster on Repurposing salmon calcitonin for activating the Hippo pathway in Glioblastoma.
Awards Fellowships Grants
- Qualified Graduate Aptitude Test in Engineering (GATE) for Life Sciences, 2017, All India Rank – 110.
- Ministry of Human Resource Development (MHRD) Fellowship, 2017-2022.
- Bayer Crop Science Fellowship, 2015-2017, For getting the first position in the entrance exam for Master's studies.
- National Talent Scholarship, ICAR, 2011-2015.
Soft Skills
- Effective Science Communicator & Engaged Presenter – Comfortable in sharing research findings through presentations and writing, with experience collaborating across disciplines.
- Thoughtful Research Planner & Careful Documenter – Experienced in designing research projects with attention to detail in data management and documentation.
- Analytical Thinker & Clear Writer – Skilled in literature review, hypothesis development, and scientific writing for publications and grants.
- Observant & Methodical Researcher – Detail-oriented with a problem-solving mindset and a commitment to independent inquiry.
- Dedicated & Goal-Focused Scientist – Strives to meet deadlines, navigate research challenges, and contribute meaningfully to projects.
- Supportive Team Member with Leadership Experience – Works well in collaborative environments, with experience mentoring junior researchers and contributing to group success.
Timeline
Graduate Student
Indian Institute of Science
08.2017 - 03.2025
MSc Project
Bidhan Chandra Krishi Viswavidyalaya
07.2016 - 06.2017
PhD - cancer Biology
Indian Institute of Science
Masters - Genetics and Plant Breeding
Bidhan Chandra Krishi Viswavidyalaya
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