Kavita Rana
Post Doctoral Fellow
Chalang Dehradun
Summary
Having a multidisciplinary background with a primary focus on capabilities with leadership qualities within diverse research teams. Having a multidisciplinary background with a primary focus on Toxicology, complemented by experience in Cancer biology and neurodegenerative studies, I possess expertise in nanoparticle therapeutics, toxicological evaluation, and diagnostic development. My proven track record includes successful involvement in DST funded projects and optimization of commercial assays. I bring together robust technical capabilities with leadership qualities within diverse research teams.
Overview
12
12
years of professional experience
Work History
Post Doctoral Fellow
IISER
06.2024 - Current
- Exploring the neural circuits associated with neurotoxin-induced Parkinson's Disease while assessing c- Fos expression, and circuit modulation through chemogenetics.
Post Doctoral Fellow
National Institute of Biologicals
08.2023 - 06.2024
- Studied protein-protein interactions in breast cancer cells.
Scientist
Dhiti Life Sci Pvt Ltd
05.2022 - 08.2023
- Led a project pertaining to the advancement of the Widal test through antigen-antibody reactions.
- Acquired proficiency in cultivating Salmonella Typhi and optimizing buffer and dye components for the assay.
- Formulated serolatex-based kits for CRP and RF qualitative assessments.
- Explored the antigen-antibody interactions, optimized buffers, and strategically sourced chemicals to enhance cost-effectiveness.
- Contributed significantly to the successful market launch of three diagnostic products.
- Institutional member of CPCSEA approved small animal facility
PI
DST, WOSA
04.2018 - 04.2021
- Conducted a research project entitled 'Effect of Arsenic-Loaded PLGA Nanoparticles on Breast Cancer Cells: An in-vitro study.'
- Established the invitro lab culture facility.
- Synthesized arsenic trioxide nanoparticles and cultivated breast cancer cell lines (MCF-7, T47D, MDA-MB-231, MDA-MB-468).
- Explored the mechanisms of apoptosis triggered by arsenic-loaded PLGA nanoparticles.
Project Assistant
DST/SERB
02.2013 - 02.2015
- Assisted in the 'Nanotoxicity of Arsenic and Cadmium Sulphide in Laboratory Rats' project.
- Investigated oxidative stress mechanisms in Albino Wistar rats exposed to nanoparticles.
Education
Ph.D. - Toxicology
08.2016 - 12.2021
Thesis Title: Nephrotoxicity of cadmium sulphide nanoparticles on Wistar rats.
Supervisor: Dr. Yeshvandra Verma
Summary: In my thesis work I investigated cytotoxicity, genotoxicity and systematic(kidney/liver) toxicity of cadmium sulphide nanoparticles on wistar rats. Explored the mechanisms of oxidative stress, generation of reactive oxygen species (ROS), production of metallothionein, accumulation of metals, levels of antioxidants, DNA damage, cell death, histopathological changes, and immuno-histochemical alterations following exposure to cadmium sulphide nanoparticles
M.Sc - Toxicology
07.2008 - 07.2010
Summer Training at CDRI, Lucknow: Worked on "Effect of Estrogen on ROS Generation in Breast Cancer
Cells.
Bachelor of Science - Zoology/Botany/Chemistry
04.2001 -
Skills
Experienced in setting up and managing new laboratory infrastructure for cell culture and toxicology studies
Publications
- Rana, K., Verma, Y., Rani, V. and Rana S.V.S., Renal toxicity of nanoparticles of cadmium sulphide in rat., Chemosphere, 193, 142 - 150, 8.9
- Rani, V., Verma, Y., Rana, K. and Rana S.V.S., Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat., Chemico - Biological Interactions, 295, 84 - 92, 5.19
- Rana, K., Verma, Y., and Rana S.V.S., Possible Mechanism of liver injury induced by cadmium sulphide nanoparticles in rat., Biological Trace Element Research, https://doi.org/10.1007/s12011-020-02128-5, 4.08
- Mishra N, Rana K, Seelam SD, Kumar R, Pandey V, Salimath BP, Agsar D., Characterization and Cytotoxicity of Pseudomonas Mediated Rhamnolipids Against Breast Cancer MDA-MB-231 Cell Line., Front Bioeng Biotechnol., 11/30/21, 10.3389/fbioe.2021., 6.06
Presentations
- Effect of Arsenic trioxide loaded PLGA nanoparticles on cellular viability of human breast cancer cells MDA - MB231., International Conference on Breakthroughs in Toxicology and Human Health [ICBTHH], 12/27/19, School of Studies in Zoology and Biochemistry, Jiwaji University, Gwalior
- Oxidative stress induced by cadmium sulphide nanoparticles in kidney of rats., International Conference on Cell Death in Cancer and Toxicology [CDCT], 02/20/18, CSIR Indian Institute of Toxicology Research, Lucknow, India
- Renal function of rats treated with nanoparticles of Cadmium., International Conference on Emerging Areas of Environmental Science and Engineering [EAESE], 02/16/17, Dept. of Environmental Science & Engineering, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, India
- Nanotoxicity of arsenic trioxide in liver and kidney of laboratory rats., National Symposium on Environmental Toxicology, 03/25/16, Dept. of Zoology, C.C.S. University, Meerut, India
Refrees
- Prof. SVS Rana Former Vice Chancellor Bundelkhand University, Emeritus Prof Toxicology Dept. CCSU, Meerut, sureshvs_rana@yahoo.com, 9719113457.
- Dr Abhinav Shrestha , Director and Chief Scientist Dhiti Life Sci Pvt Ltd, Delhi, abhinav.shrestha@oscar.net.in, 9608423875
Timeline
Post Doctoral Fellow - IISER
06.2024 - Current
Post Doctoral Fellow - National Institute of Biologicals
08.2023 - 06.2024
Scientist - Dhiti Life Sci Pvt Ltd
05.2022 - 08.2023
PI - DST, WOSA
04.2018 - 04.2021
Ch. Charan Singh University - Ph.D., Toxicology
08.2016 - 12.2021
Project Assistant - DST/SERB
02.2013 - 02.2015
Ch. Charan Singh University - M.Sc, Toxicology
07.2008 - 07.2010
Meerut College - Bachelor of Science, Zoology/Botany/Chemistry
04.2001 -
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