Lavakumar Naviri
NMR research scientist
udaipur
Summary
Analytical chemistry research professional with 19 years of experience in NMR field for structure elucidation of small, macromolecules and various biomarkers. Demonstrated ability to assign complex structures using various 1D and 2D-NMR techniques with support of FTIR and MS.
Overview
19
19
years of professional experience
6
6
years of post-secondary education
1
1
Certification
3
3
Languages
Work History
Team Leader
PI Industries LTD.
6 2021 - Current
- Managing an analytical chemistry team at product innovation analytical (PRI-Analytical). This team caters the needs of 150 synthesis chemists for routine and special studies to determine the structures of isomers, impurities and photo degradants and their mechanistic pathways etc.
- Pursuing executive MBA from one of the prestigious management institutes (IIM, Raipur) as a part of leadership development program. This course offers various subjects to enlighten the business administration skills as well as managerial skills. Business statistics, business communication, Marketing management, Economics, finance and accounts, organizational behavior are few among offered subjects.
- Leading ISO 14001, 45001 and 27001 auditees team at PRI-Analytical facility. This team defines SOPs, safety records and work instructions for various analytical activities, experiments and instruments.
- Taking responsibilities of purchase requisitions at PRI-Analytical facility.
- Successfully completed the task of full digitalization at analytical facility, right from receiving sample to archiving the analytical data.
- Leading an analytical testing team, which generates final analytical test reports and COAs. Having final approval responsibility of those ATRs and COAs.
- Responsible for assuring the structure and purity of the research chemical by verifying the analytical data (HPLC, NMR, LCMS and GC) while procuring from various CROs.
Scientific coworker
University of Regensburg
2020.01 - 2021.03
- Working on a research project titled “Investigation of charge transfer complexes by UV and NMR/ in situ UVNMR”
- Developing a methodology to bring NMR spectroscopy into the front line for investigating charge transfer complexes using various 2D NMR experiments and saturation transfer experiments
- Training Master’s students for acquiring basic 1D and 2D NMR experiments and processing spectral data.
Team Leader
PI Industries
2015.10 - 2020.01
- Successfully managed a team for impurity profiling and structure elucidation
- Supported the needs of synthesis chemists for routine and special studies to develop synthetic routes and processes, determine the structures and, mechanistic pathways
- Analyzed and confirmed structures of unexpected isomers, impurities and photo degradants using LC-MS, NMR and FTIR
- Delivered COAs along with toxicology and analytical test reports for new molecules in various projects.
Associate Manager
Syngene International
2014.06 - 2015.09
- Delivered a total of 44 NMR method validation reports of different reference standards in the span of 15 months along with the final analytical reports of impurities
- Successfully managed all GMP complied NMR activities for Baxter Health care, USA
- Supported cross functional teams in the process of manufacturing intermediates and active pharmaceutical ingredient for clinical use and followed regulations and guidelines by keeping a strong focus on quality for our patients
- Actively contributed to the development of stability analysis of active pharmaceutical ingredients and quantification methods
- Initiated the use of 13C QNMR for compounds with complicated overlap of peaks in the 1H NMR spectrum.
Associate Research Scientist
infection iMed-AstraZeneca
2013.06 - 2014.05
- Worked towards the elucidation of anti-infective agent molecular structures using 1D and 2D NMR experiments
- Actively participated in various bio NMR activities such as studying protein-ligand interactions and identifying biomarkers of tuberculosis disease
- Managed all scientific and technical NMR related activities including training synthetic chemists for processing and interpreting NMR data, periodic maintenance of NMR spectrometer, etc.
Associate Scientific Officer
GVK Biosciences
2005.05 - 2013.06
- Worked as an individual contributor as well managed several team responsibilities at NMR facility
- Led a scientific team responsible for the structure elucidation and quantification for various major pharma and agrochemical industries.
Education
MBA - Business Administration And Management
IIM Raipur
Raipur, India 2023.12 - Current
M.Sc. - Organic Chemistry
Andhra University
Andhrapradesh, India 2002.01 - 2004.04
B.Sc. - Chemistry, Physics, Mathematics
Andhra University
Andhrapradesh, India 1999.01 - 2002.04
Skills
Computer literate (Microsoft Word, Excel, PowerPoint)
Handled various NMR systems of make JEOL, VARIAN & BRUKER and their software for analyzing the data
Working experience in GLP/GMP related activities in association with various multinational companies
Advanced Techniques known: NOE, APT, DEPT, COSY, HSQC (1H-13C/15N), HMBC (1H-13C/15N), TOCSY, NOESY, DOSY, Saturation transfer experiments and J Resolved Experiments
Various other nuclei NMR such as 11B, 19F, 31P, 29Si, 77Se etc were used to determine the presence of corresponding atoms
Experience in QNMR, determination of isotopic purities and estimation of reagents’ like n-BuLi, Grignard reagents etc
Fluent English - IELTS score 70
Computer literate (Microsoft Word, Excel, PowerPoint)
Awards Certificates
- Attended GNMRS - 2020 summer school at Max Planck Institute, Gottingen, Germany.
- Certified as Outstanding performer (2014) at Indian Institute of Science (IISc), India.
- Presented a poster titled “Problems so many but only one solution (NMR) for structure elucidation” during the Science day celebrations 2013 at AstraZeneca, India. Achieved the best poster and presenter award.
- Received team of the year award (2012) at GVK Biosciences for outstanding performance and contributions to the business objectives.
Accomplishments
· Attended GNMRS - 2020 summer school at Max Planck Institute, Gottingen, Germany.
· Certified as Outstanding performer (2014) at Indian Institute of Science (IISc), India.
· Presented a poster titled “Problems so many but only one solution (NMR) for structure elucidation” during the Science day celebrations 2013 at AstraZeneca, India. Achieved the best poster and presenter award
· Received team of the year award (2012) at GVK Biosciences for outstanding performance and contributions to the business objectives
Certification
• Fluent English - IELTS score 7.0
Publications
1. Zabka M, Naviri L, Gschwind RM.
Noncovalent CH-π and π-π Interactions in Phosphoramidite Palladium (II) Complexes with Strong Conformational Preference. Angew Chem Int Ed Engl. 2021 Dec 1; 60(49):25832-25838.
2. Maruti Naik, Sandeep Ghorpade, Lalit Kumar Jena, Lava Kumar Naviri, Pallavi Khadtare, Manoranjan Panda, Pravin S. Iyer, and Monalisa Chatterji.
2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis. ACS Med Chem Lett. 2014, 5, 1005–1009.
3. Damerla VS, Tulluri C, Gundla R, Naviri L, Adepally U, Iyer PS, Murthy YL, Prabhakar N, Sen S..
Reagent-based DOS: developing a diastereoselective methodology to access spirocyclic- and fused heterocyclic ring systems. Chem Asian J. 2012, 7, 2351-60.
Timeline
MBA - Business Administration And Management
IIM Raipur
2023.12 - Current
Scientific coworker
University of Regensburg
2020.01 - 2021.03
• Fluent English - IELTS score 7.0
2019-08
Team Leader
PI Industries
2015.10 - 2020.01
Associate Manager
Syngene International
2014.06 - 2015.09
Associate Research Scientist
infection iMed-AstraZeneca
2013.06 - 2014.05
Associate Scientific Officer
GVK Biosciences
2005.05 - 2013.06
M.Sc. - Organic Chemistry
Andhra University
2002.01 - 2004.04
B.Sc. - Chemistry, Physics, Mathematics
Andhra University
1999.01 - 2002.04
Team Leader
PI Industries LTD.
6 2021 - Current