Ramakrishna Pavan Uppuluri
Visakhapatnam
Summary
Driven by a passion for pharmaceutical innovation, I excelled at Eisai Pharmaceuticals with expertise in NMR and PXRD, enhancing API analysis and polymorphic studies. Renowned for quick learning and strong work ethics, I led method validations and technology transfers, significantly improving laboratory efficiency and cross-functional team collaboration.
Overview
16
16
years of professional experience
Work History
Scientist
Eisai Pharmaceuticals India Pvt.Ltd
Visakhapatnam
11.2017 - Current
- Characterization of organic compounds using 1H, 13C, 19F, 31P, DEPT-135, DEPT-90, COSY, NOESY, HSQC, and HMBC.
- Preparation of NMR structure characterization reports.
- Quantifications using NMR.
- Calibration of NMR.
- Polymorphic studies of APIs using PXRD.
- Crystallinity calculation using PXRD.
- Peak indexing by using PXRD.
- Validations using PXRD.
- Calibration of PXRD.
- Morphology studies of APIs using a scanning electron microscope (SEM).
- Solubility studies for API(Dossier filing activities)
- Assay method validation for APIs and intermediates by HPLC.
- Related substances method validation for APIs and intermediates by HPLC.
- Degradation studies for drug substances.
- Method validations for the quantification of organic volatile solvents by GC.
- Cleaning method validation for APIs, intermediates, by HPLC.
- Method validations for particle size distribution of APIs
- Method development for particle size distribution of APIs.
- Technology transfer of analytical methods to quality control.
- Preparation protocols and reports for analytical method validations, and analytical method technology transfer.
- Preparation of the Certificate of Analysis for release samples.
- Calibration of HPLC and GC instruments.
- Responsible for laboratory incidents.
- Responsible for change controls.
Research Scientist-II
Apotex Research Pvt.Ltd
Bengaluru
01.2016 - 10.2017
- Assay method validation for APIs and intermediates by HPLC.
- Related substances method validation for APIs and intermediates by HPLC.
- Method validations for the quantification of organic volatile solvents by GC.
- Cleaning method validation for APIs, intermediates, by HPLC.
- Method validations for particle size distribution of APIs
- Method development for particle size distribution of APIs.
- Technology transfer of analytical methods to quality control.
- Responsible for laboratory incidents.
- Preparation protocols and reports for analytical method validations.
- Preparation of Certificate of Analysis for Release Samples.
- Calibration of HPLC and GC instruments.
- Polymorphic studies of APIs and formulations using PXRD.
- Crystallinity calculation using PXRD.
- Calibration of PXRD.
Management Staff
Cipla Limited
Bengaluru
10.2014 - 12.2015
- Assay method validation for APIs and intermediates by HPLC.
- Related substances method validation for APIs and intermediates by HPLC.
- Method validations for the quantification of organic volatile solvents by GC.
- Cleaning method validation for APIs, intermediates, by HPLC
- Method validations for particle size distribution of APIs
- Method development for particle size distribution of APIs.
- Technology transfer of analytical methods to quality control.
- Responsible for laboratory incidents.
- Preparation protocols and reports for analytical method validations.
- Preparation of Certificate of Analysis for Release Samples.
- Calibration of HPLC and GC instruments.
Sr.Chemist
Natco Pharma Limited
Hyderabad
06.2009 - 09.2014
- Characterization of organic compounds using 1H, 13C, 19F, 31P, DEPT-135, DEPT-90, COSY, NOESY, HSQC, and HMBC.
- Quantifications using NMR.
- Calibration of NMR.
- Polymorphic studies of APIs and formulations using PXRD.
- Validations using PXRD.
- Calibration of PXRD.
Education
M.Sc. - Analytical Chemistry
Andhra university
B.Sc. - Chemistry
Andhra University
Skills
- Good teamwork
- Positive thinking
- Dedication and proactive
- Quick learning ability to produce accuracy in time
- Good motivator of the team under all the circumstances
- Maintain good relations with the cross-functional teams
- Open to learning new things
- Strong work ethics
- Discipline and self-motivation
INSTRUMENTS HANDLED
- NMR Bruker 400 MHz (Topspin 3.6)
- PXRD Panalytical X'Pert Pro (HighScore and High Score Plus)
- PSD Malvern Master Sizer 3000, and Horiba
- SEM JEOL Touch Scope JSM-IT100
- HPLC Agilent 1260 Infinity II (Empower 3.6)
- Waters - 2695 (Empower-3.6)
- Waters - 2487 (Empower-3.6)
- Waters - 2475 (Empower 3.6)
- G.C. Agilent - 7890B (Empower 3.6)
- Agilent - 7890A (Empower-3.6)
- FTIR Bruker Alpha J, (Opus exe), Shimadzu (IR Solutions)
- KF Auto Titrator – Metrohm
Major Audits Faced
- MHRA Audit in January 2016
- US FDA Audit in January 2016
- US FDA audit in January 2017
- PMDA Audit in August 2024
Training
- Training on PXRD and polymorphism by Panalytical in February 2010
- Training on PXRD and polymorphism by Panalytical in February 2023
- Training on PXRD and polymorphism by Panalytical in February 2024
- Training on NMR by Bruker in January 2020
- Workshop on NMR in December 2024
Research Publications
Effect of Cation Size on Octahedral-Tetrahedral Equilibrium of Co2+ Aqueous Species, Research Journal of Chemistry and Environment, 17 (1), 01/01/13
Academic Distinctions
- Mandal 1st Prize for Elocution on Environmental Protection, 10/01/97
- District 2nd Prize in the Aditya Appreciation Award test, 11/01/99
Languages
- Telugu
- English
Professional Experience
16 years
Personal Information
- Father's name: U.V. Ramana Murthy
- Date of Birth: 05/31/1984
- Gender: Male
- Nationality: Indian
- Marital Status: Married
DECLARATION
I hereby declare that the information furnished above is true to the best of my knowledge
Place: (U Ramakrishna Pavan)
Date :
Timeline
Scientist
Eisai Pharmaceuticals India Pvt.Ltd
11.2017 - Current
Research Scientist-II
Apotex Research Pvt.Ltd
01.2016 - 10.2017
Management Staff
Cipla Limited
10.2014 - 12.2015
Sr.Chemist
Natco Pharma Limited
06.2009 - 09.2014
M.Sc. - Analytical Chemistry
Andhra university
B.Sc. - Chemistry
Andhra University
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