Summary
Overview
Work History
Education
Skills
Accomplishments
Certification
Publications
Patents
References
Timeline
Generic
Ramarao Vejju

Ramarao Vejju

Hyderabad

Summary

● Synthesized and delivered new molecules to Global pharma companies Early phase Drug Discovery Programs

● Developed processes for Generic API’s and Late phase molecules which were commercialized in the manufacturing plant as per the regulatory standards

● Commercialized safe scalable processes for NCE’s (Tafenoquine succinate, P276, P1446, P7345), Phosphoramidites (4), API’s (10), Intermediates (more than 100), Pheromones (3) and Insecticides (5).

● Conducted Stability studies for API’s

● Author of four patents and 13 International research publications.

● Delivered from milligram to ton scale.

● Prepared & Submitted Project proposals

● Supervised Project management through cross functional teams.

● Facility Management with integrated unit operations

● Involved in Planning and commissioning of a new Pilot plant facility

Overview

19
19
years of professional experience
1
1
Certification

Work History

Head-R&D

Chem Research Pvt td
Hyderabad
05.2019 - Current

• Heading R&D Scientific team

• Process Research and Development of API’s, NCE’s, Intermediates, Pheromones, and Agrochemicals.

• Technology transfer for commercial scale

• Route scouting, Preparation and finalization of Business proposals

• Set-up New R&D facility

• Integration of Unit operations and Research activities

Assoc. Director

Simphony pharma Life Sciences Pvt Ltd
Hyderabad
04.2017 - 04.2019

• Led R&D Scientific team

• Process Research and Development of API’s, NCE’s and Intermediates

• Synthesis of Complex API process Impurities

• Route scouting & Preparation of Business proposals

• Responsible for Kilo lab & Pilot plant activities with 20L to 500L capacity reactors

• Project Management activities & Customer relations

Head-R&D

Virchow Drugs Pvt Ltd
Hyderabad
06.2013 - 04.2017

• Led R&D Scientific team

• Route scouting & Process development for manufacturing of Generic API’s

• Monitoring of Stability studies for API’s

• Scale-up activities in Kilo lab and Pilot plant & Technology transfer from Pilot plant to manufacturing unit

• Cost reduction & process improvement activities

• Vendor qualification for key Raw materials

• Route cause analysis and CAPA implementation for batch rejections

Group Leader-R&D

Piramal Healthcare ltd
10.2010 - 05.2013

• Led up to 12 member chemists team

• Route scouting & Preparation of Business proposals

• Process development and scale-up of NCE’s and Intermediates for top global pharma companies & in-house projects

• Responsible for deliveries of up to 10kg from R&D /kilo lab / pilot plant

• Technology transfer from Kilo lab to pilot plant & manufacturing unit

• Process hazard evaluation (ARSST, RC1)

• Cost reduction & process improvement activities for existing products

• Preparation of project reports and updating to customers & Management

• Polymorphism study

• Route cause analysis and CAPA implementation for batch rejections

• Project Management activities

Manager-R&D

Neuland Laboratories Ltd
Hyderabad
08.2007 - 10.2010

• Handled the CRAMS and Medicinal chemistry projects for global pharma companies discovery programs

• Led the team of 10 chemists

• Process development and scale-up of API’s, nucleotides, and Intermediates

• Responsible for deliveries up to 20kg (from Lab & Pilot plant)

• Technology transfer for the higher scale

Assoc. Scientific Manager

Syngene International Ltd
Bangalore
10.2006 - 07.2008

• Led the medicinal chemistry FTE projects and custom synthesis projects for Drug discovery programs for global pharma companies discovery programs

• Led the team of 5 chemists

• Synthesis up to 500g of new molecules for drug discovery programs

• Responsible for literature, synthesis, characterization & delivery

• Communication with customer through telecons and e-mails

• Online Lab Note Books updation on customer network share point (Groove)

Post Doctoral Research Scholar

The University of Iowa
Iowa City
02.2005 - 08.2006

• Organic synthesis research on development of new fluorinated surfactants

• Literature search, synthesis of Analytical standards of PFOSA derivatives

• Conducting Experiments, Isolation, Purification, characterization of compounds

• Supply of analytical standards for toxic studies and material engineering studies

• Synthesis of Fluorinated surfactants with carbohydrate head group

• Study of C-N bond rotation by variable temperature NMR spectroscopy

• Operation and data interpretation of NMR (1H, 13C and 19F), IR, GC, HPLC, GC-MS instruments.

Education

Ph.D. - Organic Chemistry

Indian Institute of Chemical Technology
Hyderabad
12-2004

Master of Science - Organic Chemistry

Andhra University
Visakhapatnam
06-1998

Bachelor of Science - Maths, Physics & Chemistry

Andhra University
Visakhapatnam
05-1996

Skills

Capable of leading a multi-disciplinary scientific team

● Excellent interpersonal communication and organizational skills

● Multi step organic synthesis, Developing non-infringing process for API’s, NCE’s, and

fine Chemicals

● Expertise in handling Drug Discovery and CRAMS projects

● Technology transfer of R&D processes from Kilo lab & Pilot plant to commercial manufacturing unit

● Preparation and submission of Business proposals

● Expertise in analyzing and operating analytical instruments NMR, IR, HPLC, GC & GC-MS

● Process Hazard evaluation using ARSST, DSC & RC1 data

● GMP and GLP Compliance preparations for research and manufacturing of pharma Products

● Cost reduction & process improvement activities

● Route cause analysis (5M approach) and CAPA implementation for batch rejections

● Implementation of GMP practices through QMS

● Computer skills: MS Office (Word, Excel, PowerPoint), SciFinder, Reaxys, Chemdaw, Chemsketch & Data Science (Python Language, Machine Learning)

● Timely preparation and submission of projects status reports, MIS etc,

● Project, Communication & Meeting management with Stake holders (Customers, Management & Project team)

● Capable of handling any challenging task assigned for me

Accomplishments

● Junior Research Fellowship awarded by IICT (CSIR-INDIA) during 1999-2002.

● Senior Research Fellowship awarded by CSIR-INDIA, a federal funding agency of the Government of India in 2002-2004.

● Post doctoral research fellowship awarded by The University of Iowa, USA for NIH funded project in 2005-2006.

Certification

1. IBM certified Data Science Certificate program

2. Trained for Project Management by JEES, Hyderabad (PMI, USA approved training Institute)

Publications

1) Synthesis and Structure of Environmentally Relevant Perfluorooctane-sulfonamides Journal of Fluorine Chemistry 2007, 128 (6), 595-607.

2) Convenient One-Pot Protocol for an Exclusive Synthesis of 4-Cyano/ ethoxycarbonyl- 2,2-dimethyl-2H-chromene and/or 3-Cyano/ethoxycarbonyl-2-isopropyl- benzo[b]furan from a Single Oxo-ylide.

Synthetic Communications 2007, 37(4), 535-543.

3)   Facile Synthesis of Fluorinated 2-Aryl-5,7-bisalkylpyrazolopyrimidines from Aralkynenitriles

ARKIVOC 2006 (xii) 51-57.

4) Synthesis of Fluorine Containing N-Benzyl-1,2,3-Triazoles and N-Methyl Pyrazoles from Conjugated Alkynes.

J. Heterocyclic Chem., 2006, 43, 673-679.

5) Synthesis of Fluorine Containing 3-Cyano/ethoxycarbonyl-2-ethyl-benzo[b]furans via Microwave Assisted Tandem Intramolecular Wittig and Claisen Rearrangement Reactions.

ARKIVOC 2005 (iii) 211-220.

6) Regioselective cyclization of unsymmetrical dicyanoanilines to novel 2,3- bifunctionalised indole regioisomers and their use in the synthesis of 4,5- dihydro[1,3]oxazino[5,4-b]indole-6-carbonitriles.

Tetrahedron 2005, 61(16), 3999-4008.

7) A Facile one pot synthesis of fluorine containing 3-cyano / ethoxycarbonyl-2-methyl- benzo[b]furans.

Tetrahedron 2004, 60, 12331-37.

8) Synthesis of novel 5-trifluoromethyl-2,4,7-trisubstituted pyrido[2,3-d] pyrimidines.

Synthetic Communications 2004, 34(24), 4463-4469.

9) Microwave Assisted Intramolecular Wittig Reaction: A Facile method for the Synthesis of Conjugated Acetylenes.

Synthetic Communications 2003, 33 (9), 1523-1529.

10) Studies on the Reaction of Unsymmetrical trifluoromethyl 1,2-phenylene diamine With Various Ketones Leading to Novel Fluorinated Heterocycles.

Journal of Fluorine Chemistry 2003, 124, 203-209.

11) A Simple and Efficient Method For The Synthesis of Trifluoromethyl-benzimidazoles Under Microwave Irradiation Conditions.

Synthetic Communications 2002, 32(16), 2467-2476.

12) A Simple & Convenient method for the reduction of Nitro arenes.

Synthetic Communications 2002, 33 (18), 2849-2854.

13) A Simple and Facile Method for the Synthesis of Novel 5/7 Trifluoromethyl Substituted 4 (3H)–Quinazalone Regioisomers.

Journal of Fluorine Chemistry 2002, 118, 73-79.

Patents

New process for prepaartion of Brieracetam intermediate (R)-4-Propyldihydrofuran- 2(3H)-one (Indian Patent applied)

2) Improved process for the preparation of high pure metformine (WO2016059507A1) 3). An improved process for the preparation of dichloronitrobenzene from

dichlorobenzene. (Indian Patent, Pt-312\43861 Dt. 27/2/2001)

4). Imidazoquinolone-3-carboxamide derivatives as antibacterial agents. (Indian patent 425/2003 Dt. 18-06-2003)

References

1) Dr. P.Shanthan Rao

Chief Scientist (Retired), Fluoroorganics Division Indian Institute of Chemical Technology Hyderabad-INDIA

Mob: +91-9849221659

E-Mail: shanthanpp@yahoo.co.in

2) Dr. R Arul

President & COO

Jubilant Pharmova

Bangalore, INDIA

Tel: +91-9600008382

E-mail: arul3105@gmail.com

3) Dr. H. Sivaramakrishnan Ex-President

Piramal Enterprises Ltd., Mumbai, India.

Mob: +91-9322104612

E-mail: h_sivaram@rediffmail.com

Timeline

Head-R&D

Chem Research Pvt td
05.2019 - Current

Assoc. Director

Simphony pharma Life Sciences Pvt Ltd
04.2017 - 04.2019

Head-R&D

Virchow Drugs Pvt Ltd
06.2013 - 04.2017

Group Leader-R&D

Piramal Healthcare ltd
10.2010 - 05.2013

Manager-R&D

Neuland Laboratories Ltd
08.2007 - 10.2010

Assoc. Scientific Manager

Syngene International Ltd
10.2006 - 07.2008

Post Doctoral Research Scholar

The University of Iowa
02.2005 - 08.2006

Ph.D. - Organic Chemistry

Indian Institute of Chemical Technology

Master of Science - Organic Chemistry

Andhra University

Bachelor of Science - Maths, Physics & Chemistry

Andhra University
Ramarao Vejju