● Synthesized and delivered new molecules to Global pharma companies Early phase Drug Discovery Programs
● Developed processes for Generic API’s and Late phase molecules which were commercialized in the manufacturing plant as per the regulatory standards
● Commercialized safe scalable processes for NCE’s (Tafenoquine succinate, P276, P1446, P7345), Phosphoramidites (4), API’s (10), Intermediates (more than 100), Pheromones (3) and Insecticides (5).
● Conducted Stability studies for API’s
● Author of four patents and 13 International research publications.
● Delivered from milligram to ton scale.
● Prepared & Submitted Project proposals
● Supervised Project management through cross functional teams.
● Facility Management with integrated unit operations
● Involved in Planning and commissioning of a new Pilot plant facility
• Heading R&D Scientific team
• Process Research and Development of API’s, NCE’s, Intermediates, Pheromones, and Agrochemicals.
• Technology transfer for commercial scale
• Route scouting, Preparation and finalization of Business proposals
• Set-up New R&D facility
• Integration of Unit operations and Research activities
• Led R&D Scientific team
• Process Research and Development of API’s, NCE’s and Intermediates
• Synthesis of Complex API process Impurities
• Route scouting & Preparation of Business proposals
• Responsible for Kilo lab & Pilot plant activities with 20L to 500L capacity reactors
• Project Management activities & Customer relations
• Led R&D Scientific team
• Route scouting & Process development for manufacturing of Generic API’s
• Monitoring of Stability studies for API’s
• Scale-up activities in Kilo lab and Pilot plant & Technology transfer from Pilot plant to manufacturing unit
• Cost reduction & process improvement activities
• Vendor qualification for key Raw materials
• Route cause analysis and CAPA implementation for batch rejections
• Led up to 12 member chemists team
• Route scouting & Preparation of Business proposals
• Process development and scale-up of NCE’s and Intermediates for top global pharma companies & in-house projects
• Responsible for deliveries of up to 10kg from R&D /kilo lab / pilot plant
• Technology transfer from Kilo lab to pilot plant & manufacturing unit
• Process hazard evaluation (ARSST, RC1)
• Cost reduction & process improvement activities for existing products
• Preparation of project reports and updating to customers & Management
• Polymorphism study
• Route cause analysis and CAPA implementation for batch rejections
• Project Management activities
• Handled the CRAMS and Medicinal chemistry projects for global pharma companies discovery programs
• Led the team of 10 chemists
• Process development and scale-up of API’s, nucleotides, and Intermediates
• Responsible for deliveries up to 20kg (from Lab & Pilot plant)
• Technology transfer for the higher scale
• Led the medicinal chemistry FTE projects and custom synthesis projects for Drug discovery programs for global pharma companies discovery programs
• Led the team of 5 chemists
• Synthesis up to 500g of new molecules for drug discovery programs
• Responsible for literature, synthesis, characterization & delivery
• Communication with customer through telecons and e-mails
• Online Lab Note Books updation on customer network share point (Groove)
• Organic synthesis research on development of new fluorinated surfactants
• Literature search, synthesis of Analytical standards of PFOSA derivatives
• Conducting Experiments, Isolation, Purification, characterization of compounds
• Supply of analytical standards for toxic studies and material engineering studies
• Synthesis of Fluorinated surfactants with carbohydrate head group
• Study of C-N bond rotation by variable temperature NMR spectroscopy
• Operation and data interpretation of NMR (1H, 13C and 19F), IR, GC, HPLC, GC-MS instruments.
Capable of leading a multi-disciplinary scientific team
● Excellent interpersonal communication and organizational skills
● Multi step organic synthesis, Developing non-infringing process for API’s, NCE’s, and
fine Chemicals
● Expertise in handling Drug Discovery and CRAMS projects
● Technology transfer of R&D processes from Kilo lab & Pilot plant to commercial manufacturing unit
● Preparation and submission of Business proposals
● Expertise in analyzing and operating analytical instruments NMR, IR, HPLC, GC & GC-MS
● Process Hazard evaluation using ARSST, DSC & RC1 data
● GMP and GLP Compliance preparations for research and manufacturing of pharma Products
● Cost reduction & process improvement activities
● Route cause analysis (5M approach) and CAPA implementation for batch rejections
● Implementation of GMP practices through QMS
● Computer skills: MS Office (Word, Excel, PowerPoint), SciFinder, Reaxys, Chemdaw, Chemsketch & Data Science (Python Language, Machine Learning)
● Timely preparation and submission of projects status reports, MIS etc,
● Project, Communication & Meeting management with Stake holders (Customers, Management & Project team)
● Capable of handling any challenging task assigned for me
● Junior Research Fellowship awarded by IICT (CSIR-INDIA) during 1999-2002.
● Senior Research Fellowship awarded by CSIR-INDIA, a federal funding agency of the Government of India in 2002-2004.
● Post doctoral research fellowship awarded by The University of Iowa, USA for NIH funded project in 2005-2006.
1. IBM certified Data Science Certificate program
2. Trained for Project Management by JEES, Hyderabad (PMI, USA approved training Institute)
1) Synthesis and Structure of Environmentally Relevant Perfluorooctane-sulfonamides Journal of Fluorine Chemistry 2007, 128 (6), 595-607.
2) Convenient One-Pot Protocol for an Exclusive Synthesis of 4-Cyano/ ethoxycarbonyl- 2,2-dimethyl-2H-chromene and/or 3-Cyano/ethoxycarbonyl-2-isopropyl- benzo[b]furan from a Single Oxo-ylide.
Synthetic Communications 2007, 37(4), 535-543.
3) Facile Synthesis of Fluorinated 2-Aryl-5,7-bisalkylpyrazolopyrimidines from Aralkynenitriles
ARKIVOC 2006 (xii) 51-57.
4) Synthesis of Fluorine Containing N-Benzyl-1,2,3-Triazoles and N-Methyl Pyrazoles from Conjugated Alkynes.
J. Heterocyclic Chem., 2006, 43, 673-679.
5) Synthesis of Fluorine Containing 3-Cyano/ethoxycarbonyl-2-ethyl-benzo[b]furans via Microwave Assisted Tandem Intramolecular Wittig and Claisen Rearrangement Reactions.
ARKIVOC 2005 (iii) 211-220.
6) Regioselective cyclization of unsymmetrical dicyanoanilines to novel 2,3- bifunctionalised indole regioisomers and their use in the synthesis of 4,5- dihydro[1,3]oxazino[5,4-b]indole-6-carbonitriles.
Tetrahedron 2005, 61(16), 3999-4008.
7) A Facile one pot synthesis of fluorine containing 3-cyano / ethoxycarbonyl-2-methyl- benzo[b]furans.
Tetrahedron 2004, 60, 12331-37.
8) Synthesis of novel 5-trifluoromethyl-2,4,7-trisubstituted pyrido[2,3-d] pyrimidines.
Synthetic Communications 2004, 34(24), 4463-4469.
9) Microwave Assisted Intramolecular Wittig Reaction: A Facile method for the Synthesis of Conjugated Acetylenes.
Synthetic Communications 2003, 33 (9), 1523-1529.
10) Studies on the Reaction of Unsymmetrical trifluoromethyl 1,2-phenylene diamine With Various Ketones Leading to Novel Fluorinated Heterocycles.
Journal of Fluorine Chemistry 2003, 124, 203-209.
11) A Simple and Efficient Method For The Synthesis of Trifluoromethyl-benzimidazoles Under Microwave Irradiation Conditions.
Synthetic Communications 2002, 32(16), 2467-2476.
12) A Simple & Convenient method for the reduction of Nitro arenes.
Synthetic Communications 2002, 33 (18), 2849-2854.
13) A Simple and Facile Method for the Synthesis of Novel 5/7 Trifluoromethyl Substituted 4 (3H)–Quinazalone Regioisomers.
Journal of Fluorine Chemistry 2002, 118, 73-79.
New process for prepaartion of Brieracetam intermediate (R)-4-Propyldihydrofuran- 2(3H)-one (Indian Patent applied)
2) Improved process for the preparation of high pure metformine (WO2016059507A1) 3). An improved process for the preparation of dichloronitrobenzene from
dichlorobenzene. (Indian Patent, Pt-312\43861 Dt. 27/2/2001)
4). Imidazoquinolone-3-carboxamide derivatives as antibacterial agents. (Indian patent 425/2003 Dt. 18-06-2003)
1) Dr. P.Shanthan Rao
Chief Scientist (Retired), Fluoroorganics Division Indian Institute of Chemical Technology Hyderabad-INDIA
Mob: +91-9849221659
E-Mail: shanthanpp@yahoo.co.in
2) Dr. R Arul
President & COO
Jubilant Pharmova
Bangalore, INDIA
Tel: +91-9600008382
E-mail: arul3105@gmail.com
3) Dr. H. Sivaramakrishnan Ex-President
Piramal Enterprises Ltd., Mumbai, India.
Mob: +91-9322104612
E-mail: h_sivaram@rediffmail.com