Smitha Asoka Sahadevan

Experienced Biological Researcher specialized in chromatin and Neurobiology with 9 years of lab expertise. Seeking opportunities in translational research. Skilled in problem-solving, analysis, and meticulous data gathering. Strong leadership abilities in mentoring and adaptable in dynamic work environments. Detail-oriented, organized, and effective communicator. Proven multitasker with exceptional organizational skills.

1. BiochimBiophys Acta Gen Subj. 2018 Aug;1862(8):1729-1741. doi: 10.1016/j.bbagen.2018.05.003:Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation. Kaypee S, Sahadevan SA, Sudarshan D, Halder Sinha S, Patil S, Senapati P, Kodaganur GS, Mohiyuddin A, Dasgupta D, Kundu TK. 

2. iScience. 2018 Jun 29; 4:260-272. doi: 10.1016/j.isci.2018.06.002. Epub 2018 Jun 7.: Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation. Kaypee S, Sahadevan SA, Patil S, Ghosh P, Roy NS, Roy S, Kundu TK. 

3. CSP-TTK21 mediated p300 autoacetylation induces dendritogenesis in mice brain.Sahadevan SA, VA Vaidya, S. Banerjee and Kundu TK(manuscript under preparation)

4. Extreme disruption of heterochromatin is required for alteration in neurogenesis: Novel compensatory role of Heterochromatin Protein 1 α in PC4 knockout mice

Sahadevan SA, Gopika KG and Kundu TK(manuscript under preparation)

5. Maintenance of stable heterochromatin domains by two Non histone chromatin proteins: PC4 and HP1α

Sahadevan SA, Gopika KG and Kundu TK(manuscript under preparation)

• Oral presentation, In-House Symposium,2022, JNCASR Title of the talk: Critical crosstalk between two genome organizing proteins; PC4 and HP1α
• Poster Presentation, In-House Symposium, 2021, JNCASR Poster title: Evidence for the role of non-histone chromosomal proteins in the regulation of adult hippocampal neurogenesis
• From synapses to memory: RNA based regulatory mechanisms, NBRC, October 2018(International) Poster title: Role of lysine acetylation mediated by p300/CBP in the process of dendritogenesis.
• 6th meeting of Asian forum of chromatin and chromosome biology Meeting, CCMB, March 2017(International) Poster title: Mechanistic insights into Human Histone Chaperone NPM1-mediated modulation of p300 autoacetylation: Implications in oral cancer

• Council Of Scientific and Industrial Research, India- JRF. All India Rank-66
• Graduate Aptitude Test in Engineering, 2016. All India Rank-98 (above 95%)
• Recipient of INSPIRE Fellowship for pursuing Ph.D
• Indian Academy of Science Fellowship,2013 for Summer Internship in IISER PUNE
• Recipient of the INSPIRE scholarship, 2010-2015

• ZEISS workshop on Confocal & SR Microscopy , Sep 2017, JNCASR, Bangalore
• EMBL-EBI-IBAB workshop on Analysis of Next Generation Sequencing Data , Nov 2018 , The Institute of Bioinformatics and Applied Biotechnology , Bangalore
• Fundamentals of Advanced Concepts of Multicolor Flow Cytometry, Data analysis and presentation from Dec 2018 organized by Flowcytometry solutions, Bangalore

1. Patent filed with IPR No: BD-IPU/PAT/05/2022 for “Activators of KAT3B/p300 histone acetyltransferases and uses thereof” by D.N. Reddy*, Kundu TK#, J.Lal* and Smitha. A.S#,*CSIR-Central Drug Research Institute, Lucknow, #Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore

2. Patent (978/KOL/2015) for "A cyclometalated Iridium (III) complex to cause photoinduced cell death of cancer cells" by P.S. Ray, P. Gupta, S. Mandal, D. K. Poria and Smitha. A. S, Departments of Biological Sciences and Chemical Sciences, Indian Institute of Science Education and Research, Kolkata

1. Prof. Tapas Kumar Kundu, Professor, Molecular Biology and Genetics Unit, Jawaharlal Nehru Bangalore, INDIA-560064

E-mail – tapas@jncasr.ac.in, tapas.jnc@gmail.com

2. Dr.ParthoSarothi Ray, Associate Professor, Indian Institute of Science Education and Research, Kolkata

E-mail – psray@iiserkol.ac.in, psray40@yahoo.com